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Grants Awarded

NBIA Disorders Association has funded 24 research grants since 2002, totaling $895,480. Grants are awarded to qualified researchers to initiate pilot studies, the results of which are intended to be used to obtain larger multi-year grant funding. Many of these grants have led to the discovery of NBIA genes and the development of mouse and fruit fly disease models.

In depth information on our 3 research grants awarded in April, 2014, can be found under NEWS on our home page.

We are now accepting applications from interested researchers for research specifically for Pantothenate Kinase-Associated Neurodegeneration (PKAN), the most common form of NBIA. Please see the grant application on this page for further details. Application deadline is September 15, 2014.

  • April 2014: Manju Kurian, M.D., University College London, London, England. "Novel Therapeutic Strategies in NBIA: A Gene Therapy Approach for PLA2G6-Associated Neurodegeneration (PLAN)." $150,000.
  • April 2014: Manju Kurian, M.D., University College London, London, England. "Functional Characterization of Newly Identified NBIA Disorders Using Neuronal Cell Models." $44,680.
  • April 2014: Ana Messias, Ph.D., Helmholtz Center, Munich, Germany. "Three-dimensional structure determination and preliminary function analysis of C19orf12, a protein involved in NBIA." $45,000.
  • April 2012:  Tobias Haack, Ph.D., Helmholtz Center, Munich, Germany. “Next generation sequencing for disease gene identification and genetic testing in NBIA.” $40,000.
  • April 2012:  Ulrich Salzer, Ph.D., Medical University of Vienna, Vienna, Austria. “Type and frequency of acanthocytosis in PKAN patients and family members from the region of Cabral and possible links to neurodegeneration.” $25,000.
  • February 2012:  Roberta Leonardi, Ph.D., Dept of Infectious Diseases, St. Jude Children’s Hospital, Memphis, Tenn.  “An adeno-associated virus mediated mouse model for PKAN disease.” $30,000.
  • December 2011:  Arcangela Iuso, Ph.D., Institute of Human Genetics, Helmholtz Center, Munich, Germany.  “Development of cellular and drosophila models to characterize a newly identified NBIA gene.” $30,800.
  • December 2011:  Ody C.M. Sibon, Ph.D., University Medical Center, Groningen, Netherlands. “Investigating the potential of specific pantethine derivatives to treat PKAN.” $40,000.
  • December 2011:  Paul Kotzbauer, M.D., Ph.D., Washington University, St. Louis MO.  “Therapeutic approaches to increase Acyl Coenzyme A production in Neurodegeneration with Brain Iron Accumulation.” $40,000.
  • February 2010:  Lars Timmerman, M.D., Ph.D. & Amande Pauls, M.D., Ph.D., University of Cologne, Cologne Germany. “Stimulation of the Globus pallidus internus in patients with NBIA: prospective analysis of international therapeutic outcomes and development of a therapeutic algorithm.” $30,000.
  • November 2009:  Michael Kruer, M.D., Oregon Health & Science University, Portland OR. “SNP microarray-based disease gene discovery in idiopathic NBIA.” $30,000.
  • November 2008:  Ody C.M. Sibon, Ph.D., University Medical Center, Groningen, Netherlands. “Investigating the potential of pantethine to rescue pantothenate kinase deficiency.” $30,000.
  • November 2008:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “Proteomic Analysis of Neuroaxonal Spheroids.” $30,000.
  • December 2007:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “Towards clinical therapeutics in PKAN.” $30,000.
  • December 2007:  Paul Kotzbauer, M.D., Ph.D., Washington University, St. Louis MO.   “Combined disruption of mouse PANK2 and PLA2G6 genes to generate an improved animal model of NBIA.” $30,000.
  • December 2007:  Soma Das, Ph.D., University of Chicago, Chicago IL. “Deletion and duplication analysis of the PANK2 and PLA2G6 genes in patients with NBIA.” $30,000.
  • December 2006:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “The molecular pathogenesis of NBIA.” $30,000.
  • December 2005:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “Dynamics in brain iron distribution in PKAN.” $30,000.
  • October 2004:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “New gene discovery in NBIA.” $30,000.
  • September 2003:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “Toward rational therapies for PKAN.” $30,000.
  • September 2003:  Natalie Canham, M.B., University of Birmingham, Birmingham U.K. “Identification of the gene responsible for autosomal recessive NBIA and Congenital Cerebellar Hypoplasia.”       $30,000.
  • September 2002:  Penelope Hogarth, M.D., Oregon Health & Science University, Portland OR. “Clinical outcome measures in Hallevorden-Spatz Syndrome.”  $30,000.
  • September 2002:  Susan Hayflick, M.D., Oregon Health & Science University, Portland OR. “The biochemical basis for Hallevorden-Spatz Syndrome.” $30,000.
  • September 2002:  Han-Xiang Deng, M.D., Ph.D., Northwestern University Medical School, Chicago, IL. “Development of a mouse model of Hallevorden-Spatz Syndrome.”  $30,000.